Yes, you can and should sleep with your clear aligners in place, as they are designed to be worn for 20–22 hours a day to be effective, including during sleep. Keeping the aligners in overnight ensures continuous pressure on the teeth, which is crucial for achieving the planned tooth movements and overall treatment goals (Rossini et al., 2015). While some users may initially experience mild discomfort or tightness, especially with new trays, this typically subsides within a few days as the mouth adjusts. To enhance nighttime comfort, it’s recommended to switch to a new set of aligners just before bed, allowing your body to begin adapting during sleep when you're less aware of the pressure. Maintaining good oral hygiene before bedtime and ensuring your aligners are clean can also prevent irritation and improve sleep quality (White et al., 2017). If persistent discomfort occurs, it is best to consult your orthodontist. References: Rossini, G., Parrini, S., Castroflorio, T., Deregibus, A., & Debernardi, C. (2015). Efficacy of clear aligners in controlling orthodontic tooth movement: A systematic review. Angle Orthodontist, 85(5), 881–889. https://doi.org/10.2319/061614-436.1 White, D. W., Julien, K. C., Jacob, H. B., Campbell, P. M., & Buschang, P. H. (2017). Discomfort associated with Invisalign and traditional brackets: A randomized clinical trial. Angle Orthodontist, 87(6), 801–808. https://doi.org/10.2319/012417-62.1